PORTLAND, Ore. – Leaders across the Northwest offered condolences to those impacted by the deadliest mass shooting U.S. history.

At least 50 people were killed during a shooting at a gay nightclub in Orlando early Sunday morning.

In Portland, a vigil took place Sunday evening at NW Couch Street and Broadway. A vigil was scheduled for Thursday, organized by the Q Center and Pride NW.

Trinity Cathedral also hosted a special Eucharist and prayer vigil on Wednesday.

The Q Center, which offers support and a safe space for gay, lesbian, bisexual, and transgender people and their allies, offered counseling through their crisis line at 407-228-1446. Anyone looking for ways to help or to locate loved ones in Orlando can call the crisis line.

You can give blood through the Red Cross or through Bloodworks Northwest, which is holding a blood drive Thursday. Gay men continue to experience restrictions on donating blood.

Portland police said they would provide enhanced patrols to LGBTQ nightclubs and Pride2016 events in wake of the shooting.

Portland Mayor Charlie Hales called the shooting “shocking, horrifying, and unacceptable.”

"Next week is Portland’s Pride Parade and Festival,” Hales said. “I’m calling on all Portlanders to hold our LGBTQ community close, and come out in a show of force against terrorizing people because of who they love."

Governor Kate Brown, who just spoke at Umpqua Community College where 10 people were killed in October, urged Oregonians to find solutions.

"I call upon us as a state to move beyond the political debate about gun control and instead bring responsible gun owners and community advocates together to find solutions. We must take action to better protect community safety,” she said. "My thoughts are with the victims in Orlando, their loved ones and families, and I extend my sincere gratitude to the first responders. As Oregonians, we share in the pain and mourning reverberating across the United States and world today."

Rep. Earl Blumenauer (D-Ore.) called for action.

“Words cannot express my sorrow,” he tweeted. “Disgusted by this horrific act on the LGBT community & cowardice of those who won't pass sensible gun laws.”

Washington Governor Jay Inslee, who just attended Spokane’s Pride Parade, said the shooting was a stark turnaround from the celebratory event marked by “pride, love and joy.”

"This morning we wake up to see this horrific tragedy in Orlando. We are all waiting to learn more about the motivations of this man but there is no doubt that today is one of unimaginable sorrow for the LGBTQ community, the people of Florida, for our nation and for people everywhere who are sickened and shocked by such an act of hatred,” he said.

Muslims in Portland condemned the shooting.

“This is really tragic and sad,” said Dr. Mirza Luqman, President of Ahmadiyya Muslim Community Portland chapter. “Reverence for all human life is the essence of Islamic teaching. This is a time for prayers and efforts to stop such senseless violence in our nation.”